刘国生课题组 The Liu’s Group

Recruitment of PostDoc

2-3 Postdoctoral positions are available immediately in the Prof. Liu’s lab. Interested candidates with strong experimental experience on organic chemisty, especially on radical chemistry and transition metal catalysis, please submit a cover letter, Curriculum Vitae (including 2x references) and a short research summary to Prof. Liu, gliu@mail.sioc.ac.cn. Please put "Applications - Liu Group - PostDoc" in the subject line.

Congratulations

Congratulations to Zhongming Cheng (成忠明) and Wenzheng Fan (樊文峥) on obtaining their PhD degree.

Site-Selective sp2 C–H Cyanation of Allenes via Copper-Catalyzed Radical Relay

We communicate the site-selective cyanation of the sp2 C–H bond of allenes using the strategy of copper-catalyzed radical relay. The reactions afford various allenyl nitriles directly from simple allenes with a broad substrate scope and a remarkable functional group compatibility under mild conditions. These reactions exhibit excellent site-selectivity toward sp2 C–H, which can be attributed to the unique pocket created by the Cu-bound nitrogen-centered radical. The favorable HAT on sp2 C–H is due to crucial hydrogen bonding between the fluoride bonded to the Cu(II) center and the hydrogen atom at the allylic position. These features enable the late-stage functionalization of druglike bioactive molecules containing an allene motif. This result is published in JACS. Congratulations Zhongming Cheng.

Copper-Catalyzed Asymmetric Functionalization of Vinyl Radicals for the Access to Vinylarene Atropisomers

A novel asymmetric radical strategy for the straightforward synthesis of atropisomerically chiral vinyl arenes has been established herein, proceeding through copper-catalyzed atroposelective cyanation/azidation of aryl-substituted vinyl radicals. Critical to the success of the radical relay process is the atroposelective capture of the highly reactive vinyl radicals with chiral L*Cu(II) cyanide or azide species. Moreover, these axially chiral vinylarene products can be easily transformed into atropisomerically enriched amides and amines, enantiomerically enriched benzyl nitriles via an axis-to-center chirality transfer process, and an atropisomerically pure organocatalyst for the chemo-, diastereo-, and enantioselective (4 + 2) cyclization reaction. This result is published in JACS. Congratulations Liang Fu & Xin Chen.

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry, CAS

345 Lingling Lu, 200032 Shanghai, China

Office: Room 1305, Junmou Building

Phone: (+86) 021-54925346

Email: gliu@mail.sioc.ac.cn

Recruitment

Postdoctoral positions are available immediately in the Prof. Liu’s lab. Interested candidates with strong experimental experience on organic chemisty, especially on radical chemistry and transition metal catalysis, please submit a cover letter, Curriculum Vitae (including 2x references) and a short research summary to Prof. Liu, gliu@mail.sioc.ac.cn. Please put "Applications - Liu Group - PostDoc" in the subject line.