Enantioselective Pd(II)-Catalyzed Oxidative Aminofluorination of Unactivated Alkenes Using Et4NF·3HF as a Fluoride Source

The first asymmetric Pd(II)-catalyzed aminofluorination of unactivated alkenes using chiral quinolone-oxazolines (Quox) as ligand has been developed, which provides an easy access to a wide array of enantiomerically enriched β‐fluoropiperidines in good yields with excellent enantioselectivities. Notably, Et4NF·3HF as a readily accessible nucleophilic fluoride source was found to play an essential role in the enantioselective control, and CsOCF3 also acts a key additive to improve the excellent ee value of products. This result is published in ACIE. Congratulations Chuanqi. Read More

Site-specific Allylic C-H Bond Functionalization with a Copper-Bound N-Centred Radical

A copper-catalyzed site- and enantio-selective allylic C–H cyanation of complex alkenes was developed, where an unprecedented Cu(II)-bound N-centered radical is the key to achieve the precise site-specific HAT. This method is shown to be effective with a diverse collection of alkene-containing molecules, including sterically demanding structures and complex natural products and pharmaceuticals. This result is published in Nature. Congratulations Jiayuan Li. Read More

State Key Laboratory of Organometallic Chemistry

Shanghai Institute of Organic Chemistry, CAS

345 Lingling Lu, 200032 Shanghai, China

Office: Room 1305, Junmou Building

Phone: (+86) 021-54925346

Email: gliu@mail.sioc.ac.cn

Recruitment

Postdoctoral positions are available immediately in the Prof. Liu’s lab. Interested candidates with strong experimental experience on organic chemisty, especially on organometallic chemisty, please submit a cover letter, Curriculum Vitae (including 2x references) and a short research summary to Prof. Liu, gliu@mail.sioc.ac.cn. Please put "Applications - Liu Group - PostDoc" in the subject line.